{"id":11,"date":"2019-02-19T17:17:34","date_gmt":"2019-02-19T17:17:34","guid":{"rendered":"http:\/\/caslabs.case.edu\/lianglab\/?page_id=11"},"modified":"2026-03-23T13:10:51","modified_gmt":"2026-03-23T13:10:51","slug":"publications","status":"publish","type":"page","link":"https:\/\/caslabs.case.edu\/lianglab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

44. Mendez, S., Racca, K. J., Chikezie, K. C., Kumar, S., Liang, F. -S., Guo, Z. -F.,* Lei, X. Unexpected dominance of meta substitution in N-amidothiourea Zn(II) sensors: Enhanced affinity, sensitivity and turn-on fluorescence. J. Mol. Struct. <\/em>2026, 1365, 146008. Link<\/a><\/p>\n

43. Dong, C.,#<\/sup> Li, S.,#<\/sup> Xia, X., Tran, T. H., Kumar, S., Yu, H., Win, Y., Li, S., He, Yi., Cai, J.,* Liang, F. -S.* Cyclic gamma-AApeptide-based molecular glues for RNA m6A editing. ACS Chem. Biol. <\/em>2026, 21, 439. Link<\/a><\/p>\n

42. Nguyen, H. C., Liang, F. -S.* Leveraging cell’s endogenous regulatory network: towards safer and more effective CAR T cell therapies for solid tumors. Transl. Cancer Res. <\/em>2026, 15, 2. Link<\/a><\/p>\n

41. Rauff, R., Dong, C., Ayyar, S., Liang, F. -S.* Transcript and temporal-specific RNA nucleotide editing technologies. Bioorg. Med. Chem. <\/em>2025, 130, 118346. Link<\/a><\/p>\n

40. Nguyen, H. C., Kim, B.-G., Myers, J. T., Yan, H., Kumar, S., Eid, S., Wang, W., Huang, A. Y.,* Liang, F. -S.* Engineering TME-gated inducible CAR-T cell therapy for solid tumors. Mol. Ther. <\/em>2025, 33, 3473. Link<\/a><\/p>\n

*Commentary: “Hypoxia-regulatable CAR-T cells”. Mol. Ther. <\/em>2025, 33, P3473. Link<\/a><\/p>\n

39. Nguyen, H. C., Song, Y., Kumar, S., Liang, F. -S.* A customizable platform to integrate CAR and conditional expression of immunotherapeutics in T cells. Int. J. Mol. Sci. <\/em>2024, 25, 10568. Link<\/a><\/p>\n

38. Zhou, C., Wagner, S., Liang, F. -S.* Induced Proximity Labeling and Editing for Epigenetic Research. Cell Chem. Biol. <\/em>2024. doi.org\/10.1016\/j.chembiol.2024.05.005. Link<\/a><\/p>\n

37. Xu, Y., Wang, Y., Liang, F. -S.* Site-Specific m6A Erasing via Conditionally Stabilized CRISPR-Cas13b Editor. Angew. Chem. Int. Ed.<\/em> 2023. 62, e202309291. Link<\/a><\/p>\n

36. Chen, J.,#<\/sup> Nguyen, H.,#<\/sup> Yang, M., Zeng, F., Xu, Hang, Liang, F. -S.,* Wang, W.* A Theranostic Abscisic Acid-based Molecular Glue. Chem. Sci.<\/em> 2023, 14, 3377. Link<\/a><\/p>\n

35. Xu, Y., Tian, N., Shi, H., Zhou, C., Wang, Y., Liang, F. -S.* A Split CRISPR\/Cas13b System for Conditional RNA Regulation and Editing. J. Am. Chem. Soc.\u00a0<\/em>2023, 145, 5561. Link<\/a><\/p>\n

34. Liang, F. -S.* Xu, Y. RNA Epigenetics and Epitranscriptomics: The Emerging Gene Regulatory Landscape Through RNA Modifications. Encyclopedia of Cell Biology. Elsevier, 2023, 580. Link<\/a><\/p>\n

33. Xu, Y.,#<\/sup> Wang, Y.,#<\/sup> Liang, F. -S.* A CRISPR-based Strategy for Temporally Controlled Site-Specific Editing of RNA Modifications. Bio-protoc. 2023, 13, e4607. Link<\/a><\/p>\n

32. Xu, Y., Liang, F. -S.* On demand CRISPR-mediated RNA N6-Methyladenosine Editing. Genes & Diseases<\/em> 2022, <\/em>doi.org\/10.1016\/j.gendis.2022.05.019. Link<\/a><\/p>\n

31. Bhattarai, U., Liang, F. -S.* MicroRNAs and Other Noncoding RNAs in Human Pathology. MicroRNA: From Bench<\/span> to Bedside<\/span><\/em>, Elsevier, 2022, 469. Link<\/a><\/p>\n

30. Shi, H.,#<\/sup> Xu, Y.,#<\/sup> Tian, N., Yang, M., Liang, F. -S.* Inducible and Reversible RNA N6-Methyladenosine Editing. Nat. Commun.<\/em> 2022, 13, 1958. <\/em>Link<\/a>
\n<\/em><\/p>\n

*Highlighted in CWRU Daily<\/em> (Link<\/a>) and Phys.org (Link<\/a>).<\/p>\n

29. Zhao, W.,#<\/sup> Xu, Y.,#<\/sup> Wang, Y., Gao, D., King, J., Xu, Y., Liang, F. -S.* Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR\/dCas\u2011based epigenome editing and gene activation. Sci. Rep.<\/em> 2021, 11, <\/em>15912. <\/em>Link<\/a><\/p>\n

28. Zhao, W., Wang, Y., Liang, F. -S.* Chemical and light inducible epigenome editing. Int. J. Mol. Sci. 2020, 21, <\/em>998. <\/em>Link<\/a><\/p>\n

27. Bhattarai, U.,#<\/sup> Hsieh, W. -C.,#<\/sup> Yan, H., Guo, Z. -F., Shaikh, A. Y., Soltani, A., Song, Y., Ly, D. H.,*<\/sup> Liang, F. -S.* Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor. Bioorg. Med. Chem.<\/em>\u00a02020, 28, <\/em>115394. <\/em>Link<\/a><\/p>\n

26. Yan, H., Liang, F. -S.* “miRNA inhibition by proximity-enabled Dicer inactivation” Methods.<\/em> 2019, 167<\/em>, 117. Link<\/a><\/p>\n

25. Yan, H., Zhou, M., Bhattarai, U., Song, Y., Zheng, M., Cai, J.,* Liang, F. -S.* Cyclic peptidomimetics as inhibitor for miR-155 biogenesis. Mol. Pharm<\/em>. 2019, 16<\/em>, 914. Link<\/a><\/p>\n

24. Zeng, G., Wang, Y., Bruchez, M., Liang, F. -S.* A Self-Reporting Chemically Induced Protein Proximity System Based on a Malachite Green Derivative and the L5** Fluorogen Activating Protein.\u00a0Bioconjugate Chem. <\/i>2018,<\/i> 29<\/em>, 3010. Link<\/a><\/p>\n

23. Yan, H., Bhattarai, U., Song, Y., Liang, F. -S.* Design, synthesis and activity of light deactivatable microRNA inhibitor.\u00a0Bioorg. Chem.<\/i> 2018, 80<\/em>, 492. Link<\/a><\/p>\n

22. Zhao, W., Nguyen, H, Zeng, G., Gao, D. Yan H., Liang, F-S.* “Chemically Induced Proximity System Engineered from the Plant Auxin Signaling Pathway”\u00a0Chem. Sci.<\/em>\u00a02018,\u00a09,<\/em> 5822. Link<\/a><\/p>\n

21. Gao, D., Liang, F-S.* “Chemical Inducible dCas9-guided Editing of H3K27 Acetylation in Mammalain Cells”\u00a0Methods Mol. Biol.<\/em>\u00a02018,\u00a01767,<\/em> 429. Link<\/a><\/p>\n

20. Chen, T.#<\/sup>, Gao, D.#<\/sup>, Zhang, R., Zeng, G.,Yan, H., Lim, E., Liang, F-S.* “Chemically Controlled Epigenome Editing Through an Inducible dCas9 System”\u00a0J. Am. Chem. Soc.\u00a0<\/em>2017, 139<\/em>, 11337. Link<\/a><\/p>\n

19. Yan, H., Bhattarai, U., Guo, Z., Liang, F. -S.* “Regulating miRNA-21 Biogenesis by Bi-functional Small Molecules<\/span>”\u00a0J. Am. Chem. Soc.\u00a0<\/em>2017,\u00a0139,<\/em>\u00a04987.\u00a0Link<\/a><\/p>\n

18.\u00a0Zeng, G.#<\/sup>, Li, H.#<\/sup>, Wei, Y., Xuan, W., Zhang, R., Breden, L. E., Wang, W.*,\u00a0Liang, F. -S.* “Engineering Iron Responses in Mammalian Cells by Signal-Induced Protein Proximity”\u00a0ACS Synth. Biol.\u00a0<\/em>2017,\u00a06,<\/em>\u00a0921.\u00a0Link<\/a><\/p>\n

17. Xuan, W., Pan, R., Li, G., Cao, Y., Liang, F. -S., Liu, K.*, Wang, W.* “Reaction-based “off-on” fluorescent probe enabling detection of endogenous labile Fe2+ and imaging Zn2+-induced Fe2+ flux in living cells and elevated Fe2+ in ischemic stroke”\u00a0Bioconjugate Chem.\u00a0<\/em>2016,\u00a027,<\/em>\u00a0302.\u00a0Link<\/a><\/p>\n

16. Zeng, G., Xuan, W., Zhang, R., Wang, W., Liang, F. -S.* “Constructing\u00a0de novo<\/em>\u00a0H2O2 Signaling via Induced Protein Proximity”\u00a0ACS Chem. Biol.\u00a0<\/em>2015,\u00a010,<\/em>\u00a01404.\u00a0Link<\/a><\/p>\n

15. Wright, C. W., Guo, Z. -F, Liang, F. -S.* “Light control of cellular processes using photocaged abscisic acid”\u00a0ChemBioChem,\u00a0<\/em>2015,16,<\/em>\u00a0254.\u00a0Link<\/a><\/p>\n

14. Guo, Z. -F., Zhang, R., Liang, F. -S.* “Facile Functionalization of FK506 for Biological Studies by the Thiol-Ene \u2018Click\u2019 Reaction”RSC Adv.<\/em>, 2014,\u00a04<\/em>, 11400.\u00a0Link<\/a><\/p>\n

13. Jin, Q., Liang, F. -S.* “Chemical Tools for Spatiotemporal Regulation of microRNAs”\u00a0Org. Chem. Curr. Res.\u00a0<\/em>\u00a02013,\u00a02<\/em>, e121.\u00a0Link<\/a><\/p>\n

12. Liang, F. -S., Crabtree, G. R. “Small Molecule Induced Proximity”\u00a0Chembiomolecular Science: at the Frontier of Chemistry and Biology<\/em>, 2012, 115.\u00a0Link<\/a><\/p>\n

11. Liang, F. -S., Ho, W. Q., Crabtree, G. R. “Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity”\u00a0Sci. Signal.<\/em>\u00a02011,\u00a04<\/em>, rs2.\u00a0Link<\/a><\/p>\n

*Highlighted in: “Inducible Gene Expression in Mammals: Plants Add to the Menu” Sci. Signal.<\/em>\u00a02011,\u00a04<\/em>, pe13.\u00a0Link; <\/a>“ABA Remastered”\u00a0Nat. Struct. Mol. Biol.<\/em>\u00a02011,\u00a018<\/em>, 403.\u00a0Link<\/a><\/p>\n

10. Liang, F. -S., Crabtree, G. R. “Developmental Biology: The Early Heart Remodelled”\u00a0Nature<\/em>\u00a02009,\u00a0459<\/em>, 654.\u00a0Link<\/a><\/p>\n

9. Liang, F. -S., Greenberg, W. A., Hammond, J. A., Hoffmann, J, Head, S. R., Wong, C. -H. “Evaluation of RNA Binding Specificity of Aminoglycosides with DNA Microarrays”\u00a0Proc. Natl. Acad. Sci. U.S.A.<\/em>\u00a02006,\u00a0103<\/em>, 12311.\u00a0Link<\/a><\/p>\n

8. Liang, F. -S., Brik, A., Lin, Y.-C., Elder, J. H., Wong, C. -H. “Epoxide Opening in Water for Rapid Inhibitor Discovery in Microtiter Plate and in situ Screening”\u00a0Bioorg. Med. Chem.\u00a0<\/em>2006,\u00a014<\/em>, 1058.\u00a0Link<\/a><\/p>\n

7. Fridman, M., Belakhov, V., Lee, L. V., Liang, F. -S., Wong, C. -H. & Baasov, T. “Dual Effect of Synthetic Aminoglycosides: Antibacterial Activity Against Bacillus anthracis and Inhibition of Anthrax Lethal Factor”\u00a0Angew. Chem. Int. Ed.\u00a0<\/em>2005,\u00a044<\/em>, 447.\u00a0Link<\/a><\/p>\n

6. Liang, F. -S., Wang, S.-K., Nakatani, T. & Wong, C. -H. “Targeting RNAs by Tobramycin Analogs”\u00a0Angew. Chem. Int. Ed.\u00a0<\/em>2004,\u00a043<\/em>, 6496.\u00a0Link<\/a><\/p>\n

5. Wu, C. -Y., Jan, J. -T., Ma, S. -H., Kuo, C. -J., Juan, H. -F., Cheng, Y. -S. E., Hsu, H. -H., Huang, H. -C., Wu, D., Brik, A., Liang, F. -S., Liu, R. -S., Fang, J. -M., Chen, S. -T., Liang, P. H., Wong, C. -H. “Small Molecules Targeting Severe Acute Respiratory Syndrome Human Coronavirus”\u00a0Proc. Natl. Acad. Sci. U.S.A.<\/em>\u00a02004,\u00a0101<\/em>, 10012.\u00a0Link<\/a><\/p>\n

4. Lee, L. V., Bower, K. E., Liang, F. -S., Shi, J., Wu, D., Sucheck, S. J., Vogt, P. K., Wong, C. -H. “Inhibition of the Proteolytic Activity of Anthrax Lethal Factor by Aminoglycosides”\u00a0J. Am. Soc. Chem.\u00a0<\/em>2004,\u00a0126<\/em>, 4774.\u00a0Link<\/a><\/p>\n

3. Agnelli, F., Sucheck, S. J., Marby, K. A., Rabuka, D., Yao, S. -L., Sears, P. S., Liang, F. -S., Wong, C. -H. “Dimeric Aminoglycosides as Antibiotics”\u00a0Angew. Chem. Int. Ed.<\/em>\u00a02004,\u00a043<\/em>, 1562.\u00a0Link<\/a><\/p>\n

2. Wong, C. -H., Liang, F. -S. “Surface Plasmon Resonance Study of RNA-Aminoglycoside Interactions”\u00a0Methods Enzymol.\u00a0<\/em>2003,\u00a0362<\/em>, 340.\u00a0Link<\/a><\/p>\n

1. Ho, T. -L., Liang, F. -S. “Synthesis of ent-Herbasolide”\u00a0Chem. Commun.<\/em>\u00a01996, 1887.\u00a0Link<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

44. Mendez, S., Racca, K. J., Chikezie, K. C., Kumar, S., Liang, F. -S., Guo, Z. -F.,* Lei, X. Unexpected dominance of meta substitution in N-amidothiourea Zn(II) sensors: Enhanced affinity, sensitivity and turn-on fluorescence. J. Mol. Struct. <\/em>2026, 1365, 146008. Link<\/a><\/p>\n

43. Dong, C.,# Li, S.,# Xia, X., Tran, T. H., Kumar, S., Yu, H., Win, Y., Li, S., He, Yi., Cai, J.,* Liang, F. -S.* Cyclic gamma-AApeptide-based molecular glues for RNA m6A editing. ACS Chem. Biol. <\/em>2026, 21, 439. Link<\/a><\/p>\n

42. Nguyen, H. C., Liang, F. -S.* Leveraging cell’s endogenous regulatory network: towards safer and more effective CAR T cell therapies for solid tumors.<\/p>\n

Continue reading… Publications<\/span><\/a><\/p>\n","protected":false},"author":19,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/pages\/11"}],"collection":[{"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":10,"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":531,"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/pages\/11\/revisions\/531"}],"wp:attachment":[{"href":"https:\/\/caslabs.case.edu\/lianglab\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}