Comprehensive Organometallic Chemistry III<\/strong><\/span> has a great set of chapters on Experimental Methods and Techniques.\u00a0 In particular please see chapter 1.07 \u201cExperimental Methods and Techniques: Basic Techniques\u201d for details on vacuum and Schlenk techniques.\u00a0 This entire book is online and available via our library, and you can download each chapter as a pdf file. <\/span><\/p>\n Aldrich Technical Bulletins<\/a><\/strong><\/span> provide very useful and *free* guides for handling various types of chemicals, especially for air- and water-sensitive reagents.\u00a0 They also provide instructions for other types of operations.\u00a0 Bulletins AL-134<\/a> and Al-164<\/a> are of particular importance for CHEM 331 students for handling reagents.<\/span><\/p>\n How do you use that glassware and apparatus?<\/strong><\/span>\u00a0 Check out Rob Toreki\u2019s Glassware Gallery<\/a>!\u00a0 Lots of good descriptions.<\/span><\/p>\n How pure is your NMR spectrum?<\/span><\/strong>\u00a0 Please consult this great resource:\u00a0 Fulmer, G. R.; Miller, A. J. M.; Sherden, N. H.; Gottlieb, H. E.; Nudelman, A.; Stoltz, B. M.; Bercaw, J. E.; Goldberg, K. I., NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist<\/a>. Organometallics 2010, 29 (9), 2176-2179.<\/span><\/p>\n Titration of organometallic reagents-two different methods are used in this course:<\/strong><\/span><\/p>\n In addition, there is a great handout<\/a> Prof. David Emslie at the McMaster University has prepared discussing the titration of these types of reagents that should definitely be consulted.\u00a0 Thanks David!.<\/span><\/p>\n A nice series of papers are listed below in which the authors took the time and effort to actually measure the efficacy of various drying methods for different solvent types.<\/span><\/p>\n Desiccant efficiency in solvent drying. A reappraisal by application of a novel method for solvent water assay<\/span> \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Good for solvents such as Acetontrile, Benzene, and Dioxane<\/a><\/span><\/p>\n Desiccant efficiency in solvent drying. 3. Dipolar aprotic solvents<\/span> \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Good for dipolar solvents such as HMPT and DMP<\/a>: <\/span><\/p>\n Desiccant efficiency in solvent and reagent drying. 7. Alcohols<\/span> \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":" Comprehensive Organometallic Chemistry III<\/strong> has a great set of chapters on Experimental Methods and Techniques.\u00a0 In particular please see chapter 1.07 \u201cExperimental Methods and Techniques: Basic Techniques\u201d for details on vacuum and Schlenk techniques.\u00a0 This entire book is online and available via our library, and you can download each chapter as a pdf file. <\/p>\n Aldrich Technical Bulletins<\/a><\/strong> provide very useful and *free* guides for handling various types of chemicals, especially for air- and water-sensitive reagents.\u00a0 They also provide instructions for other types of operations.\u00a0 Bulletins AL-134<\/a> and Al-164<\/a> are of particular importance for CHEM 331 students for handling reagents.<\/p>\n
\nAlison Frontier from the University of Rochester has a spectacular website Not Vodoo X<\/a><\/strong> that is a gold mine of tips and techniques for practicing synthesis chemists. \u00a0A MUST SEE website!!<\/h3>\n
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\nGot Dry Solvents?\u00a0 <\/strong><\/span><\/h4>\n
\nDavid R. Burfield, Kim-Her Lee, Roger H. Smithers<\/span>
\nJournal of Organic Chemistry<\/em> 1977,<\/strong> 42<\/em> (18), 3060-3065\u00a0 <\/span><\/p>\n
\nDavid R. Burfield, Roger H. Smithers<\/span>
\nJournal of Organic Chemistry<\/em> 1978,<\/strong> 43<\/em> (20), 3966-3968<\/span><\/p>\n
\n<\/span>David R. Burfield, Roger H. Smithers
\n<\/span>Journal of Organic Chemistry<\/span><\/em> 1983,<\/span><\/strong> 48<\/span><\/em> (14), 2420-2422
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